On the photo you can see the cello's bad condition on walks, which was typical at the time. The patch on the upper arm and the shaved area on the hind leg show the places where the biopsies for the examination at the University of Munich were taken.

So now the diagnosis was there, but no solution yet. Based on human therapies, Cello was given all the dietary supplements in high doses that are usually given with this defect – even after a long time without any noticeable change. His exercise intolerance remained.
In the summer of 2018 he was so powerless that he was only willing to walk steeper paths uphill if he was forced to. On September 12, 2018, he only just managed to jump into my van, which has a step-in height of 57 cm.
We were permanent guests of various veterinarians, because due to the constantly low energy production, damage to various organs in the body was gradually becoming apparent: e.g. cardiac arrhythmia, KCS (keratoconjunctivitis sicca, "dry" eye) and symptoms of dementia.
It became increasingly clear that Cello was showing symptoms of CDS (cognitive dysfunction syndrome = dementia). Now and then he showed no reaction to verbal commands from me. So he once ran unimpressed towards a busy street and didn't react at all to my verbal increases. I had to fall down and hold him, to which he reacted in astonishment. In other words, nothing had arrived in his brain, the signal processing was not working properly. Another time he got his long legs tangled up at the top of a steep, narrow stairway: he was standing four steps up with his front legs and his hind legs still attached to the foot; the stairs. Unhappily he stood there sprawled and couldn't think of a solution strategy for the problem. Because he didn't know what to do, I had to help him. Then he sometimes stopped suddenly in the middle of running and seemed disoriented and lost. If he heard human voices nearby at such a moment, he listened hard, as if he wanted to check whether something there at least sounded familiar to him. My speech didn't get through to him at all, I had to leash him and take him with me. The strongest sign of the onset of dementia was a disorientation that began at night, which made him wander around restlessly and look into corners. After a change of location, he behaved like this during the day in the new place, which he is actually very familiar with.
Luckily, a doctor's advice was very helpful here, as high dosages of Karsivan daily have helped curb Cello's confusion through improved blood flow. But at best a CDS stagnates, Karsivan cannot heal it.

We stumbled upon David Sinclair’s You Tube posts by chance and the reference to mitochondrial strengthening by NMN electrified us. It was very clear: Cello had to and would get NMN! In any case, high doses of vitamins and coenzyme Q10 are already being used in mitochondrial therapy. So it was only logical for us that NMN as a derivative of the B3 could also be considered.
Cello has been receiving NMN since November 2019, now 1.5g a day. Less than 14 days after the first dose, he was already developing an energy rush that took the form of wild “gambling’ immediately noticed by several family members.

His condition in autumn 2019 was so sad that he often just trotted behind on walks. He was no longer interested in males at all (a very bad sign!), females could only get his attention; arouse briefly. Again and again was dhe way back on walks was so difficult that we had to be picked up by car. And if he ran a little too much, there was a high risk of overexertion, so that he ended up “on the ropes” for several days. hung. He didn't want to get to know people's walks any more, it was difficult to get Cello out of the car.